Sjögren’s syndrome, hepatitis C virus and B-Cell lymphoproliferation. Common immunopathogenic mechanisms
نویسندگان
چکیده
El virus de la hepatitis C (VHC) posee un triple tropismo, hepatotropo, linfotropo y sialotropo. Los pacientes con infección por VHC pueden presentar diversas manifestaciones extrahepáticas que simulan las principales manifestaciones clínicas, inmunológicas e histológicas características del síndrome de Sjögren (SS) primario. Los pacientes VHC+ que presenten un síndrome seco pueden ser diagnosticados erróneamente como SS primario. De todas formas, existen diversas características clínicas e inmunológicas que pueden permitirnos diferenciar ambas situaciones. Los pacientes SS-VHC presentan una elevada frecuencia de crioglobulinémia e hipocomplementemia, así como una menor prevalencia de anticuerpos anti-Ro/SS-A y anti-La/SS-B comparado con pacientes con SS primario, así como un patrón de citocinas circulante Th2. Actualmente, la infección crónica por VHC, el SS, la crioglobulinemia y el linfoma B deben ser considerados como procesos estrechamente relacionados entre sí.
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